The best doses for this supplement have not been established. Studies have used varying doses, depending on several factors (including the condition being treated).
(Click DHEA Dosage for more information.)
While low doses of DHEA are often well tolerated, high doses can cause significant side effects, including (but not limited to):
- Facial and body hair growth (hirsutism)
- Hair loss
- Deepening of the voice
- Menstrual irregularity
- High blood pressure (hypertension).
(Click DHEA Side Effects to learn more, including potentially serious side effects that you should report immediately to your healthcare provider.)
DHEA may potentially interact with a number of medications (see DHEA Drug Interactions).
Many people may be able to take low doses of DHEA safely for short periods of time. However, long-term, high-dose use is probably not safe. Some people may be more likely to experience problems due to the supplement. Therefore, you should talk with your healthcare provider prior to taking it if you have:
- Cancer (or a history of cancer)
- Uterine fibroids
- High cholesterol
- Liver disease, such as liver failure, cirrhosis, or hepatitis
- Bipolar disorder (also known as manic depression)
- Polycystic ovary syndrome (PCOS)
- Any chronic or severe health problems
- Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant (see DHEA and Pregnancy)
- Breastfeeding (see DHEA and Breastfeeding).
Make sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
(Click Is DHEA Safe? for more information, including any available warnings and precautions.)