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Staxyn Drug Interactions

CYP 3A4 Inhibitor Medications
The body breaks down Staxyn using enzymes in the liver known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inhibitors) can decrease the activity of these enzymes. Combining Staxyn with one of these CYP 3A4 inhibitors may increase the level of Staxyn in your body, increasing your risk for more side effects. Your healthcare provider may recommend another medication for erectile dysfunction if you take a CYP 3A4 inhibitor.
 
Nitrates
Staxyn should not be used in combination with nitrate medications, including prescription nitrates or recreational drugs that contain nitrate (amyl nitrite or butyl nitrite, sometimes called "poppers"). Taking these medications together may decrease your blood pressure to unsafe levels. You should not use Staxyn even if you use a nitrate very infrequently, because you cannot predict when you might need the nitrate. You must wait at least 24 hours after taking Staxyn to use a nitrate.
 
Other Phosphodiesterase Type-5 Inhibitors (PDE5 Inhibitors)
Staxyn is a PDE5 inhibitor and should not be used in combination with other PDE5 inhibitors. Using more than one PDE5 inhibitor will increase the risk of serious side effects. Because PDE5 inhibitors are sometimes used for treating other conditions, such as pulmonary hypertension, make sure to talk to your healthcare provider before taking a medication for erectile dysfunction if you are already taking Staxyn.
 
Sapropterin
Taking Staxyn in combination with sapropterin may cause your blood pressure to decrease too much. If your blood pressure drops too low, you may experience symptoms such as dizziness, lightheadedness, or fainting. Your healthcare provider may choose to monitor your blood pressure more closely if you take these medications together.
 
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Staxyn Medication Information

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