Tribulus

Tribulus is a toxic plant commonly used in dietary supplements for improving athletic performance and enhancing sexual function. Early research shows that it may increase the level of various male hormones, which may be helpful for sexual problems or bodybuilding. However, there is not enough scientific evidence to suggest that Tribulus is indeed effective for these claimed uses.

What Is Tribulus?

Tribulus (also known as puncture vine) is a flowering plant that is usually considered a toxic weed. It has sharp spines that can puncture bicycle tires. It is a popular ingredient in dietary supplements, most often used to enhance sexual function or to improve athletic performance.
 
(Click Tribulus Benefits for more information on what the supplement is used for.)
 

Potential Side Effects

This supplement has not been reported to cause side effects. However, there are several different side effects that might theoretically occur, based on how the supplement works.
 
(Click Tribulus Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
 

Safety Concerns With Tribulus

Short-term use of Tribulus appears to be relatively safe in many circumstances. However, some people may be more likely to experience problems than others. Therefore, you should talk with your healthcare provider prior to taking the supplement if you have:
 
Also, let your healthcare provider know if you are:
 
Make sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 
(Click Tribulus Safety for more information, including any available warnings and precautions.)
 

How Does It Work?

Tribulus contains a mixture of different compounds that may be responsible for the medicinal properties of the plant. The root, stem, and fruit contain these compounds. Early research suggests that the plant may increase the level of various hormones (including testosterone and dehydroepiandrosterone, or DHEA) in rats. Although studies have not shown similar effects in humans, people use the supplement for sexual problems and for bodybuilding based on the assumption that it increases hormone levels.
 
Tribulus may help relax the arteries of the heart. It also may lower blood pressure by inhibiting angiotensin-converting enzymes (much like ACE inhibitor medications). Research also suggests that the plant might have a diuretic effect (it may increase urine production), which may be why some people use if for various kidney problems.
 

Is Tribulus Effective?

In general, there is not enough scientific evidence to suggest that Tribulus really is effective for most uses (see Does Tribulus Terrestris Work? for more information).
 

Dosing Information

There is no established standard dose for Tribulus, although general dosing guidelines may be obtained from a few clinical studies that evaluated certain uses of the supplement (see Tribulus Dosage for more information).
 

Tribulus Drug Interactions

Theoretically, Tribulus may interact with a few medications (see Drug Interactions With Tribulus).
 

What If I Take an Overdose?

It is not known exactly what to expect from an overdose of this supplement. If you think you or someone else may have taken too much Tribulus, it is important to seek immediate medical attention.
 
(Click Tribulus Terrestris Overdose for more information.)
 

How Should Tribulus Be Stored?

Refer to the label of your individual product for information on how to best store Tribulus supplements. Keep all medications and supplements out of the reach of children.
 
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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