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Viagra Drug Interactions

Viagra Drug Interactions Explained

The following sections explain in detail the following interactions that can occur when Viagra is combined with any of the drugs listed above.

 

Cimetidine

In previous research studies, when cimetidine and Viagra were given at the same time, the levels of Viagra in the blood increased significantly. To avoid this possible Viagra drug interaction, it is recommended that you discuss cimetidine alternatives with your healthcare provider prior to taking Viagra.
 
CYP 3A4 Inhibitors
Viagra is broken down ("metabolized") by certain enzymes in the liver known as CYP 3A4 enzymes. Certain other medications (known as CYP 3A4 inhibitors) decrease the activity of the enzymes, thereby increasing the level of Viagra in the blood. This may lead to serious side effects in some cases. Check with your healthcare provider before taking Viagra with a CYP 3A4 inhibitor.
  
Alpha Blockers
In previous research studies, when alpha blockers and Viagra were used at the same time for people with benign prostatic hyperplasia (BPH) or high blood pressure, blood pressure decreased. Also, some people experienced lightheadedness, dizziness, or fainting when standing from either a sitting position or lying down. Taking a Viagra dosage above 25 mg within four hours of taking an alpha blocker is not recommended. Check with your healthcare provider before taking Viagra with an alpha blocker.
 
Blood Pressure Medications
Taking Viagra in combination with a high blood pressure medication may cause your blood pressure to decrease too much. Check with your healthcare provider before taking Viagra with a blood pressure medicine.
 
Nitrates
If you are taking nitrates, you should not use Viagra. Even if you use a nitrate very infrequently, you should not take Viagra (since you cannot predict when you will need to take the nitrate).
 
Other Phosphodiesterase Type 5 Inhibitors (PDE5 Inhibitors)
Viagra is a PDE5 inhibitor and should not be combined with other such medications.
  
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